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Top 100 Biotechnology Companies
The following is a list of the top 100 biotechnology companies ranked by revenue.
The first six companies qualify for the list of the top 50 pharmaceutical companies.
Rank 2004 |
Company |
Country |
Revenue 2004 (USD millions) |
R&D 2004 (USD millions) |
Net Income/ (Loss) 2004 (USD millions) |
Employees 2004 |
1 |
Amgen |
USA |
10,550.0 |
2,028.0 |
2,363.0 |
14,400 |
2 |
Genentech |
USA |
4,621.2 |
947.5 |
784.8 |
7,646 |
3 |
Serono |
Switzerland |
2,458.1 |
594.3 |
496.2 |
4,902 |
4 |
Biogen Idec |
USA |
2,211.6 |
687.7 |
25.1 |
4,266 |
5 |
Genzyme |
USA |
2,201.1 |
391.8 |
86.5 |
7,000 |
6 |
Chiron Corp. |
USA |
1,723.4 |
431.1 |
78.9 |
5,400 |
7 |
Gilead Sciences |
USA |
1,324.6 |
223.6 |
449.4 |
1,654 |
8 |
CSL |
Australia |
1,273.4 |
70.2 |
152.4 |
8,000 |
9 |
MedImmune |
USA |
1,141.1 |
327.3 |
-3.8 |
1,823 |
10 |
Cephalon |
USA |
1,015.4 |
274.0 |
-73.8 |
2,173 |
11 |
Millennium Pharmaceuticals |
USA |
448.2 |
402.6 |
-252.3 |
1,477 |
12 |
Genencor International |
USA |
470.4 |
75.8 |
26.8 |
1,271 |
13 |
ImClone Systems |
USA |
388.7 |
82.1 |
113.7 |
866 |
14 |
Actelion |
Switzerland |
379.7 |
109.7 |
70.2 |
850 |
15 |
Celgene |
USA |
377.5 |
160.9 |
52.8 |
766 |
16 |
MGI Pharma |
USA |
195.7 |
62.6 |
-85.7 |
282 |
17 |
QLT |
Canada |
186.1 |
50.1 |
165.7 |
520 |
18 |
Nabi Biopharmaceuticals |
USA |
179.8 |
61.0 |
-50.4 |
727 |
19 |
AEterna Zentaris |
Canada |
179.2 |
23.3 |
-4.4 |
350 |
20 |
Regeneron Pharmaceuticals |
USA |
174.0 |
136.1 |
41.7 |
730 |
21 |
Enzon Pharmaceuticals |
USA |
169.6 |
34.8 |
1.9 |
359 |
22 |
Ligand Pharmaceuticals |
USA |
168.8 |
70.7 |
n/a |
n/a |
23 |
Berna Biotech |
Switzerland |
164.6 |
42.1 |
-18.8 |
887 |
24 |
Acambis |
UK |
156.7 |
53.0 |
38.3 |
270 |
25 |
InterMune |
USA |
151.0 |
81.3 |
-59.5 |
326 |
26 |
Cangene |
Canada |
120.5 |
19.7 |
25.0 |
600 |
27 |
Vertex Pharmaceuticals |
USA |
102.7 |
192.2 |
-166.2 |
736 |
28 |
Protein Design Labs |
USA |
91.0 |
122.6 |
-53.2 |
660 |
29 |
Innogenetics |
Belgium |
88.4 |
34.9 |
-17.0 |
600 |
30 |
Neurocrine Biosciences |
USA |
85.2 |
115.1 |
-45.8 |
385 |
31 |
Transkaryotic Therapies |
USA |
78.1 |
88.1 |
-65.9 |
400 |
32 |
Icos |
USA |
74.6 |
71.8 |
-198.2 |
675 |
33 |
United Therapeutics |
USA |
73.6 |
30.6 |
15.4 |
170 |
34 |
LifeCell |
USA |
61.1 |
7.9 |
7.2 |
196 |
35 |
Myriad Genetics |
USA |
56.6 |
50.7 |
-40.6 |
511 |
36 |
OSI Pharmaceuticals |
USA |
42.8 |
110.4 |
-260.4 |
452 |
37 |
Isis Pharmaceuticals |
USA |
42.6 |
118.5 |
-142.9 |
303 |
38 |
Bioniche Life Sciences |
Canada |
41.8 |
10.5 |
-6.0 |
305 |
39 |
Enzo Biochem |
USA |
41.6 |
8.1 |
-6.2 |
238 |
40 |
ID Biomedical |
Canada |
41.2 |
37.3 |
-30.5 |
511 |
41 |
Protherics |
UK |
38.4 |
6.7 |
2.3 |
219 |
42 |
ViroLogic |
USA |
36.8 |
7.8 |
-81.8 |
250 |
43 |
ZymoGenetics |
USA |
35.7 |
94.3 |
-88.8 |
410 |
44 |
Peptech |
Australia |
33.6 |
3.2 |
19.9 |
20 |
45 |
Antisoma |
UK |
33.1 |
30.3 |
-1.1 |
63 |
46 |
Carrington Laboratories |
USA |
30.8 |
0.9 |
0.0 |
324 |
47 |
Cell Therapeutics |
USA |
29.6 |
101.1 |
-252.3 |
402 |
48 |
Cambridge Antibody Technology |
UK |
28.6 |
79.1 |
-68.4 |
281 |
49 |
Crucell |
The Netherlands |
28.1 |
25.5 |
-26.5 |
210 |
50 |
Vernalis |
UK |
27.9 |
44.7 |
44.7 |
131 |
51 |
Bavarian Nordic |
Denmark |
27.5 |
23.3 |
-8.9 |
117 |
52 |
MorphoSys |
Germany |
27.3 |
15.4 |
0.6 |
132 |
53 |
Anika Therapeutics |
USA |
26.5 |
4.1 |
11.2 |
61 |
54 |
ImmunoGen |
USA |
26.0 |
22.2 |
-6.0 |
146 |
55 |
Corixa |
USA |
25.0 |
62.3 |
-77.0 |
263 |
56 |
AnGes MG |
Japan |
24.9 |
34.0 |
-14.2 |
85 |
57 |
SciClone Pharmaceuticals |
USA |
24.4 |
18.0 |
-13.3 |
143 |
58 |
Kosan Biosciences |
USA |
22.9 |
40.2 |
-22.1 |
136 |
59 |
ViroPharma |
USA |
22.4 |
16.4 |
-19.5 |
36 |
60 |
Agenix |
Australia |
22.2 |
4.3 |
-8.7 |
100 |
61 |
Tanox |
USA |
20.5 |
27.2 |
-10.3 |
127 |
62 |
CV Therapeutics |
USA |
20.4 |
124.3 |
-155.1 |
265 |
63 |
NeuroSearch |
Denmark |
20.4 |
23.5 |
0.2 |
175 |
64 |
Indevus Pharmaceuticals |
USA |
18.7 |
23.3 |
-68.2 |
356 |
65 |
BioMarin Pharmaceutical |
USA |
18.6 |
49.8 |
-187.4 |
359 |
66 |
Dyax |
USA |
16.6 |
39.4 |
-33.1 |
100 |
67 |
MediGene |
Germany |
16.3 |
18.3 |
-15.3 |
117 |
68 |
Maxygen |
USA |
16.3 |
53.3 |
8.3 |
230 |
69 |
Abgenix |
USA |
16.1 |
124.8 |
-187.5 |
523 |
70 |
GPC Biotech |
Germany |
15.7 |
50.0 |
-49.7 |
171 |
77 |
Cytogen |
USA |
14.6 |
3.2 |
-20.5 |
89 |
72 |
Genta |
USA |
14.6 |
71.5 |
-32.7 |
73 |
73 |
Vical |
USA |
14.5 |
31.2 |
-23.7 |
169 |
74 |
NPS Pharmaceuticals |
USA |
14.2 |
143.1 |
-168.3 |
356 |
75 |
ML Laboratories |
UK |
14.2 |
23.1 |
-16.2 |
115 |
76 |
Vitrolife |
Sweden |
14.1 |
1.7 |
1.6 |
70 |
77 |
Cerus |
USA |
13.9 |
27.7 |
-31.2 |
83 |
78 |
Encysive Pharmaceuticals |
USA |
13.8 |
58.1 |
-54.7 |
117 |
79 |
Arena Pharmaceuticals |
USA |
13.7 |
57.7 |
-58.0 |
291 |
80 |
Medarex |
USA |
12.5 |
122.0 |
-186.5 |
435 |
81 |
Amrad |
Australia |
12.1 |
9.6 |
-2.6 |
38 |
82 |
Life Therapeutics |
Australia |
12.0 |
1.5 |
-7.2 |
133 |
83 |
GenVec |
USA |
11.9 |
23.1 |
-18.9 |
111 |
84 |
Medivir |
Sweden |
11.6 |
26.1 |
-15.1 |
126 |
85 |
Cell Genesys |
USA |
11.5 |
92.1 |
-97.4 |
377 |
86 |
Inex Pharmaceuticals |
Canada |
11.2 |
20.6 |
-25.9 |
62 |
87 |
Inspire Pharmaceuticals |
USA |
11.1 |
25.7 |
-44.1 |
165 |
88 |
Myogen |
USA |
9.9 |
54.1 |
-57.7 |
100 |
89 |
Targeted Genetics |
USA |
9.7 |
17.3 |
-14.3 |
90 |
90 |
Epimmune |
USA |
9.6 |
10.9 |
-3.9 |
37 |
91 |
Progenics Pharmaceuticals |
USA |
9.6 |
36.1 |
-42.0 |
136 |
92 |
Active Biotech |
Sweden |
9.5 |
32.6 |
-23.7 |
151 |
93 |
GroPep |
Australia |
9.1 |
3.1 |
0.7 |
85 |
94 |
Novogen |
Australia |
8.8 |
5.7 |
-8.7 |
67 |
95 |
Unigene Laboratories |
USA |
8.4 |
10.7 |
-5.9 |
61 |
96 |
Vicuron Pharmaceuticals |
USA |
8.4 |
68.5 |
-80.0 |
216 |
97 |
Xenova |
UK |
8.4 |
24.0 |
-23.0 |
75 |
98 |
Dusa Pharmaceuticals |
USA |
8.0 |
6.5 |
-15.6 |
65 |
99 |
Senetek |
USA |
7.6 |
1.5 |
0.6 |
11 |
100 |
Valentis |
USA |
7.5 |
10.1 |
-6.5 |
22 |
" Source: Top 100 biotechnology companies, MedAdNews, July 2005 "